Efficacy of Dexamethasone as A Prophylaxis for Radiation-Induced Pain Flare after Palliative Radiotherapy for Symptomatic Bone Metastases

Dexamethasone in the prophylaxis of radiation-induced pain flare after palliative radiotherapy for bone metastases: a double-blind, randomised placebo-controlled, phase 3 trial.

BACKGROUND Pain flare occurs after palliative radiotherapy, and dexamethasone has shown potential for prevention of such flare. We aimed to compare the efficacy of dexamethasone with that of placebo in terms of reduction of incidence of pain flare. METHODS In this double-blind, randomised, placebo-controlled phase 3 trial, patients from 23 Canadian centres were randomly allocated (1:1) with a...

Incidence of pain flare following palliative radiotherapy for symptomatic bone metastases: multicenter prospective observational study

BACKGROUND Palliative radiotherapy (RT) is an effective treatment for symptomatic bone metastases. Pain flare, a transient worsening of the bone pain after RT, has been described in previous reports with different incidence rates. The aim of the study was to prospectively evaluate the incidence of pain flare following RT for painful bone metastases and evaluate its effects on pain control and f...

the effect of systemic steroids on the incidence of bone pain flare with palliative irradiation

background : a significant number of patients who receive palliative irradiation for painful bone metastases experience pain flare, defined as a distressing transient increase in pain not immediately controlled by additional analgesics. this pain is postulated to be due to edema at the onset of radiotherapy. this study aims to compare the incidence of bone pain flare among patients who receive ...

Palliative radiotherapy for bone metastases: an ASTRO evidence-based guideline.

PURPOSE To present guidance for patients and physicians regarding the use of radiotherapy in the treatment of bone metastases according to current published evidence and complemented by expert opinion. METHODS AND MATERIALS A systematic search of the National Library of Medicine's PubMed database between 1998 and 2009 yielded 4,287 candidate original research articles potentially applicable t...

Intraperitoneal Dexamethasone As A New Method for Relieving Postoperative Shoulder Pain after Gynecologic Laparoscopy